High Risk Population Information

COVID-19 Vaccine

The CDC's Advisory Committee on Immunization Practices has identified the purposes of a COVID-19 vaccine as (1) decrease death and serious disease, (2) preserve functioning of society, (3) reduce extra burden that COVID-19 is having on people already facing disparities and (4) increase the chance for everyone to enjoy health and well-being.


The vaccine will be made available based on ethical principles of maximizing benefits, minimizing harm, striving for equity, justice and fairness, and making transparent decisions. Ethical considerations include prioritizing Missourians who have been disproportionally impacted by the COVID-19 pandemic. Missouri’s Advisory Committee for Equitable COVID-19 Vaccine Distribution meets weekly and includes partners from the Missouri Hospital Association, Missouri State Medical Association, Missouri Pharmacy Association, Missouri Center for Public Health Excellence, Missouri Primary Care Association, Missouri Academy of Family Physicians, Missouri Health Care Association, St. Louis City Department of Health, Kansas City Health Department, Missouri Nurses Association, Mid-America Regional Council, Urban League of St. Louis, Missouri Chapter of NAACP, Hispanic Chamber of Commerce of St. Louis, Missouri Catholic Conference and Casa de Salud. Additionally, the state of Missouri is vetting vaccinators before they receive an allotment of vaccines.


Vaccines will be opened up to all Missourians and distributed to convenient locations as availability increases. See our graphic below.


Three of the four most advanced vaccines require two doses that are administered at least 21 days apart. It is important patients return for the second dose to develop the highest level of immunity.


Safety First

Safety is incorporated into every level of a vaccine’s development cycle. Clinical trials are an important part of determining vaccine safety and efficacy. Currently, Pfizer, Moderna and Janssen have completed phase 3 clinical trials involving tens thousands of participants. The trials determined the safety and efficacy of the vaccines in thousands of participants. The purpose of clinical trials is to generate scientific data and other information for the Food and Drug Administration to review and base their recommendations on. Today, millions of Americans have received both doses of the Pfizer and Moderna mRNA vaccines.

The safety and efficacy data has also been reviewed by an independent expert committee called the Advisory Committee on Immunization Practices (ACIP), which also recommended the vaccines for emergency use. Pfizer’s clinical trial enrolled 44,000+ participants with 42% globally having racially and ethnically diverse backgrounds. Of Moderna’s 30,000 trial participants, 37% were from minority communities, including 6,000 Hispanic and 3,000 Black participants. Janssen’s trial included 43,783 participants in the United States, Latin America and South Africa. AstraZeneca’s initial trial data included participants from Brazil and the United Kingdom while the company continues to conduct trials in South Africa, Kenya, Latin America, Japan, Russia and the United States.

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Free Vaccination

We are committed to providing a free COVID-19 vaccination experience to all Missourians, including those without insurance. No person can be billed for the COVID-19 vaccine. Vaccination providers may charge an administration fee to insurance, Medicaid or Medicare, if applicable in your situation. Uninsured Missourians will be able to receive the vaccination regardless of their health insurance status.

When can I get vaccinated?

The state of Missouri is currently working to vaccinate residents that are eligible under our phased approach.
COVID-19 Vaccine Availability COVID-19 Vaccine Availability

Phase 1B – Tier 1

Protecting those who keep us safe and help us during an emergency

  • Public Health Administrators and Staff
  • Law Enforcement
  • Fire Services
  • Corrections
  • Emergency Management
  • Public Works
  • Emergency Services

Phase 1B – Tier 2

Protecting those who are at increased risk for severe illness

  • Anyone 65 and older
  • Any adults with:
    • Cancer
    • Chronic Kidney Disease
    • COPD
    • Heart Conditions
    • Weakened immune system due to organ transplant
    • Severe obesity (BMI >40)
    • Pregnancy
    • Sickle Cell Disease
    • Type 2 Diabetes Mellitus
    • Individuals with intellectual and/or developmental disabilities such as Down Syndrome

Phase 1B – Tier 3

Protecting those who keep the essential functions of society running

  • Education (K-12)
  • Childcare
  • Communications Infrastructure
  • Dams Sector
  • Energy Sector
  • Food & Agriculture Sector 1
  • Government
  • Information Technology
  • Nuclear Reactor Sector
  • Transportation Systems
  • Water and Wastewater Systems


Lifesaving Vaccine

COVID-19 vaccines are lifesaving developments. Vaccinations have saved hundreds of millions of lives over the last century. Scientists have developed vaccines for Smallpox, Polio, Measles, Mumps, Rubella, Hepatitis, Meningitis and more. Data from clinical trials indicate:

  • 95% efficacy rate for Pfizer’s vaccine
  • 94.5% efficacy rate for Moderna’s vaccine
  • 85% efficacy rate (for preventing severe disease) for Janssen's vaccine
  • 90% efficacy rate for AstraZeneca’s vaccine (not yet authorized for emergency use in U.S.)
The different types of vaccines were not studied in head-to-head comparisons or trials; therefore, they should not be compared to each other.


Please use the resources below to find vaccinators or mass vaccination events in your area.